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Fast-cleaving RNAs reveal an even faster on-pathway intermediate (I). Time course of self-cleavage of RS19 fittoa first-order equation (dashed line) or the Pre → I → Rz·S on-pathway intermediate model (solid line; see text). (Inset) Complete time course demonstrates that the data fit well to both equations after the lag phase; x axis, time (s); y axis, fraction cleaved.
