Figure 3.

Effect of pre- and post-treatment with the kinin B₂ receptor antagonists on the mechanical hyperalgesia induced by formalin in gastrocnemius muscle. (A) HOE 140 or (B) FR173657 was administered i.p. 30 min before the formalin injection and hyperalgesia was assessed 3, 6 and 24 h after the formalin injection. (C) HOE 140 was administered i.p. 24 h after the formalin injection (post-treatment). The hyperalgesia was assessed 0.5, 2 and 4 h after DALBK injection. B, represents the baseline measurement (immediately before formalin injection). Data represent the mean ± SEM (n= 5–7). The symbols denote a significant difference: *P < 0.05 compared to the naive group and ^#P < 0.05 compared to the formalin i.m. group. Statistical analyses were performed using one-way anova (repeated measures) followed by Bonferroni's test.