Table 1.
Effect of B1 and B2 antagonists and standard analgesic drugs on the hyperalgesia induced by formalin
| Treatment | AUC (mean ± SEM) | Supported weight (% of naive group) |
|---|---|---|
| Naive | 7916 ± 212 | 100 ± 2.6 |
| Formalin | 3015 ± 286* | 38 ± 3.6* |
| Formalin + DALBK (1 mg·kg−1 i.p.) | 5227 ± 470# | 66 ± 5.9# |
| Formalin + HOE 140 (0.057 mg·kg−1 i.p.) | 4875 ± 298# | 61 ± 3.8# |
| Formalin + Dipyrone (120 mg /kg i.p.) | 6384 ± 892# | 80 ± 11# |
| Formalin + Celecoxib (30 mg·kg−1 i.p.) | 7985 ± 412# | 100 ± 5.2# |
| Formalin + Morphine (10 mg·kg−1 s.c.) | 5925 ± 338# | 75 ± 4.2# |
| Formalin + Gabapentin (70 mg·kg−1 p.o.) | 5482 ± 403# | 69 ± 5# |
Data represent the mean ± SEM (n= 6). Mechanical hyperalgesia was evaluated at 3, 6 and 24 h after formalin injection. The drugs were administered 30 min before formalin via i.p., s.c. or p.o. The area was calculated as the AUC for each individual treatment. Statistical analysis was performed using one-way anova followed by Bonferroni's test. The symbols denote a significant difference, *P < 0.05 compared to the naive group and #P < 0.05 compared to the formalin group.