Skip to main content
. 2012 Jun;166(4):1261–1271. doi: 10.1111/j.1476-5381.2012.01848.x

Figure 2.

Figure 2

Blockade of the effect of exogenous intra-articular CGRP administration on the endothelial cell proliferation index using the specific CGRP receptor antagonist BIBN4096BS. Bar 1 shows the baseline PCNA index in naïve animals, negative control. Bar 2 shows the response to saline alone injection, which was not significantly different from naïve control. Bar 3 shows the PCNA index in animals intra-articularly injected with saline and i.v. injected with the CGRP receptor antagonist BIBN 4096BS. Intra-articular saline did not significantly increase the PCNA index, negative control. Bar 4 shows the effect of intra-articular administration of 2.5 nmol CGRP (positive control) on the PCNA index. The effect of CGRP on the PCNA index was diminished by the CGRP receptor antagonist BIBN406BS (bars 5 and 6) when compared with CGRP injection alone. Rats were given CGRP 2.5 nmol alone or together with BIBN406BS at either 0.07 µmol per rat (bar 5) 0.7 µmol per rat (bar 6). P < 0.001 for both treatments. Data shown are means ± SD; n = 6 rats per group.