Table 1.
dAUC to phenylephrine response between control and experimental situations in endothelium-intact (E+) MRAs from WKY rats and SHR untreated or treated with pioglitazone and in endothelium-denuded segments (E−) of arteries from pioglitazone-treated SHR
| SHR + Pio | ||||
|---|---|---|---|---|
| WKY E+ | SHR E+ | E+ | E− | |
| NS 398 | ∼0 | ∼0 | 34.5 ± 6.9# | 13.2 ± 3.7+ |
| SQ 29,548 | ND | ∼0 | 19.5 ± 3.1# | ∼0+ |
| SC 19220 | ND | ∼0 | ∼0 | ND |
| RO 1138452 | ND | ND | ∼0 | ND |
| SQ 29,548 + RO 1138452 | ND | ND | 23.5 ± 5.8 | ND |
| Furegrelate | ND | ∼0 | ∼0 | ND |
| Tranylcypromine | ND | ∼0 | 16.0 ± 1.6# | ND |
| Apocynin | 14.2 ± 4.2 | 29.3 ± 4.3* | ∼0# | ND |
| Allopurinol | ∼0 | 15.0 ± 2.2* | ∼0# | ND |
| L-NAME | 51.9 ± 5.4 | 32.4 ± 4.9* | 53.6 ± 4.2# | ND |
AUCs were calculated from the individual concentration–response curve plots using a computer program (GraphPad Prism Software); the differences are expressed as a percentage of the AUC of the corresponding control situation. ND, not determined.
*P < 0.05 versus WKY rats, #P < 0.05 versus SHR untreated rats, +P < 0.05 versus endothelium-intact arteries by Student's t-test. n= 5–10 animals. Data are expressed as mean ± SEM.