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Accessible surface area representation of the ThKaiA180C structure and residue substitutions producing an altered circadian oscillator phenotype identified in S. elongatus KaiA as mapped at this domain. The accessible surface area for each substituted residue is colored in magenta or blue for the two monomeric subunits. The groove formed between α3 and α4 and α3′ and α4′ is indicated by a dashed arrow. Several of the circadian phenotype substitutions map at this groove.
