Figure 8.

Inhibition of native TRPM7-like currents in HEK 293 cells by NS8593. (A) Representative current density–voltage relationships of native whole-cell currents (MIC) induced by depletion of internal Mg²⁺ in HEK 293 cells. Measurements were performed as in Figure 2A. The insert shows the corresponding currents over time measured at −100 and +100 mV. Current density–voltage relationships were acquired at time points as indicated by arrows. (B) Analysis of current density amplitudes at +100 mV acquired before and after current induction or after application of NS8593 as indicated by arrows in (A). Numbers above columns indicate the number of cells measured; ***P≤ 0.001 (t-test).