Table 1.

Organic compounds inhibiting TRPM7 currents

Compound	IC50 (µM)*	Description of the block	Reference
2-APB	178	Reversible	Prakriya and Lewis, 2002, Li et al., 2006
Spermine	2.3†	Reversible, voltage dependent	Kozak et al., 2002
Carvacrol	306	Reversible	Parnas et al., 2009
NDGA	n.d.	Tested only at 10 and 20 µM	Chen et al., 2010b
AA861	n.d.	Tested only at 10 and 40 µM	Chen et al., 2010b
MK886	n.d.	Tested only at 20 µM	Chen et al., 2010b
Nafamostat mesylate	617	Reversible, voltage and extracellular divalents dependent	Chen et al., 2010a
Waixenicin A	7.0	Irreversible, [Mg2+]i dependent	Zierler et al., 2011
NS8593	1.6	Reversible, [Mg2+]i dependent	Present study

^*IC₅₀ values were determined for recombinant TRPM7 in patch-clamp measurements in the absence of internal Mg²⁺.

^†The dose-dependent effect of spermine was evaluated on endogenous MIC currents in divalent-free external solution.

n.d., not determined.