Table 2.

Apparent affinity of wild-type and mutant TRPM7 channels to NS8593

	IC50 (µM)
TRPM7 variants	[Mg2+]I free	300 µM [Mg2+]i
Wild type	1.6 ± 0.1	5.9 ± 0.6
Y1049P	0.47 ± 0.03	1.9 ± 0.2