Figure 1.

Carrageenan-induced knee joint incapacitation, 6 h after its intra-articular administration in rats. Right knee, 30 min before injection of saline (control group) or λ-carrageenan (2%, 25 µL), received, alone or in combination, fasitibant chloride (100 µg), dexamethasone (100 µg), dexketoprofen (300 µg), des-Arg⁹-[Leu⁸]-bradykinin (DALBK; 100 µg), atenolol (50 µg) or MK571 (100 µg). Data are the mean ± SEM of 6–12 rats. °P < 0.05, significantly different from the control group; unpaired Student's t-test and *P < 0.05, significantly different from the carrageenan-treated group; one-way anova followed by Dunnett's post-test. Dotted lines indicate the control value (upper) and the response after carrageenan treatment (lower).