Figure 2.

Graphs show the effect of various pharmacological agents on the electro-mechanical coupling in anaesthetized guinea pigs. Drugs with high TdP risk (quinidine, haloperidol, domperidone, terfenadine, dofetilide and thioridazine) induced unequal changes of the QT interval versus the QLVP_end interval, whereas drugs with low (amiodarone, moxifloxacin and ciprofloxacin), or no TdP risk (vehicle, salbutamol and diltiazem) induced parallel changes of the QT interval and LVP_end interval. Finally, isoprenaline showed different kinetics of its effect on the QT and QLVP_end interval leading to a transient decrease of the E-M window. Plots show mean ± SEM.