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. 2012 May;166(2):737–748. doi: 10.1111/j.1476-5381.2011.01801.x

Figure 6.

Figure 6

JK-P3 inhibits endothelial tube formation in response to VEGF-A or bFGF. (A) Endothelial tubulogenesis stimulated by the presence of VEGF-A or bFGF in an endothelial-fibroblast co-culture model was evaluated for the effects of JK-P3 over a 7-day period. (B) High-resolution fluorescent images depicting endothelial cell phenotypes and filopodia formation during tubulogenesis in the presence of JK-P3. (C) Quantification of endothelial tube length and (D) quantification of endothelial tube branch point formation. Quantification performed using Image J software. Data are presented as mean± SEM (n≥ 10). Significant difference denoted by **P < 0.01 or ***P < 0.001 using anova.