Table 2.
Inhibition of VEGFR2, FGFR1 and FGFR3 tyrosine kinase activity by JK-P compounds
| IC50 value (µM) | Ki value (µM) | |||||
|---|---|---|---|---|---|---|
| Compound | VEGFR2 | FGFR1 | FGFR3 | VEGFR2 | FGFR1 | FGFR3 |
| JK-P3 | 7.83 ± 0.66 | 27.0 ± 0.18 | 5.18 ± 0.30 | 5.65 ± 0.48 | 7.71 ± 0.07 | 3.97 ± 0.23 |
| JK-P5 | 7.28 ± 0.19 | 11.4 ± 0.71 | 3.21 ± 0.15 | 5.26 ± 0.13 | 3.25 ± 0.20 | 2.46 ± 0.11 |
JK-P3 and JK-P5 differentially inhibited the intrinsic tyrosine kinase activity of all three receptors. IC50 curves and Ki values were generated using an in vitro kinase assay (see Methods section).