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Comparison of mAb efficacy in the murine sepsis model.
| mAb | Number of Balb/c mice surviving Hours post challenge | Total (%) | P | ||||
|---|---|---|---|---|---|---|---|
| 0 | 24 | 48 | 72 | 96 | |||
| CS-D7 | 20 | 20 | 20 | 17 | 14 | 4 (70%) | *<0.001 |
| CS-D7·N297A | 20 | 20 | 20 | 15 | 12 | 12 (60%) | †0.4852 |
| 20C2HA | 30 | 28 | 21 | 8 | 4 | 4 (13%) | |
Comparison of survival with CS-D7 versus survival with isotype control 20C2HA.
Comparison of survival with CS-D7·N297A versus survival with CS-D7.
