Table 7.
Serum cytokine levels after passive immunization with one of two mAbs and challenge with S. aureus SA025.
| Cytokine (Time post challenge, h) | pg cytokine/mL serum mean (std dev), n = 5 | |
|---|---|---|
| CS-D7 | 20C2HA | |
| IFN-γ (0) | 0 (0)* | 0 (0)* |
| (4) | 3 (3) | 11 (12) |
| (24) | 79 (40) | 42 (24) |
| (48) | 54 (24)† | 22 (16) |
| IL6 (0) | 0 (0)* | 1 (6)* |
| (4) | 114 (53)‡ | 209 (38) |
| (24) | 73 (27)§ | 195 (50) |
| (48) | 295 (157) | 412 (343) |
| KCGRO (0) | 20 (18)* | 48 (36)* |
| (4) | 760 (57) | 634 (163) |
| (24) | 365 (127)** | 570 (169) |
| (48) | 574 (182) | 426 (180) |
*
P < 0.001 comparing cytokine concentration at time 0 to time points 4, 24, and 48 h.
†
P = 0.03 comparing IFN-γ concentration in CS-D7 treated versus 20C2HA treated animals at 48 h.
‡
P = 0.005 comparing IL6 concentration in CS-D7 treated versus 20C2HA treated animals at 4 h post challenge.
§
P = 0.0004 comparing IL6 concentration in CS-D7 treated versus 20C2HA treated animals at 24 h post challenge.
**
P = 0.04 comparing KCGRO concentration at time 24 h in CS-D7 treated versus 20C2HA treated animals.