Table 1.
Phosphorylation sites of tau-protein
| T 181 |
S 198 |
S 199 |
S 202 |
T 205 |
S 208 |
S 210 |
T 212 |
S 214 |
T 217 |
T 231 |
S 235 |
S 262 |
S 396 |
S 400 |
T 403 |
S 404 |
S 409 |
S 412 |
S 413 |
S 422 |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PHF | ○ | ○ | ○ | ◎ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ◎ | ○ | |
| TPKI | ○ | ○ | ○ | ◎ | |||||||||||||||||
| TPKII | ○ | ◎ | ○ | ○ | |||||||||||||||||
| GSK3 α | ○ | ○ | ○ | ||||||||||||||||||
| cdc2 | ○ | ◎ | ○ | ○ | |||||||||||||||||
| MAPK | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | |||||||||||||
| 35/41 Kinase | ○ | ○ | |||||||||||||||||||
| Brain Kinase | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ||||||||||||
| PKA | ○ |
The first line shows candidate sites for phosphorylation in tau protein, numbered according to the amino acid sequence from N-terminus. The second line shows the sites phosphorylated in native tau protein. The third line and below show the sites phosphorylated by the kinases indicated in the left column. ○ indicates the site phosphorylated by the kinase shown in the left column. ◎ indicates the site specifically phosphorylated by TPKI or TPKII.