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. 2012 Aug 9;3:226. doi: 10.3389/fmicb.2012.00226

Figure 3.

Figure 3

Minimum inhibitory concentration assay for F. novicida and FosR#2 mutant. Wild-type F. novicida susceptibility to fosmidomycin (A) and compound 1 (B). Wild-type MIC for fosmidomycin is 121 μM. [WT IC50 for fosmidomycin is 0.092 mg/l (95% CI = 0.079–0.107 mg/l)]. Wild-type MIC for compound 1 is 203 μm. Wild-type IC50 for compound 1 is 11.99 mg/l (95% CI = 9.84–14.62 mg/l, R2 = 0.972). FosR#2 mutant resistance to fosmidomycin (C) FosR#2 and susceptibility to compound 1 (D). F. novicida glpT mutant MIC or IC50 for fosmidomycin could not be defined due to lack of inhibition (R2 value for fitness = 0.38). FosR#2 mutant MIC for compound 1 is approximately 203 μM. The IC50 for compound 1 is 24.38 mg/l (95% CI = 18.75–31.70 mg/l, R2 = 0.944).