Figure 4.

Sensitivity of wild-type F. novicida and glpT transposon insertion mutants to fosmidomycin, FR900098, and compound 1. Sensitivity of F. novicida is shown to all three compounds, to fosmidomycin (white bar), FR900098 (gray bar), and the lipophilic prodrug of FR900098, or compound 1 (black bar). Fosmidomycin, FR900098, and compound 1 were tested at concentrations of 200 μg/ml. Resistance of glpT transposon insertion mutants to fosmidomycin (white bar) and to a lesser extent FR900098 (gray bar), but not compound 1 (black bar) is shown. No inhibition was seen using fosmidomycin and the transposon mutants. For this experiment, n = 3 and error bars represent SEM, and in some cases are too small to be seen.