Table 1.

Effect of rapamycin on body weight and select serum chemistry in non-diabetic (db/m) and diabetic (db/db) male mice

	db/m–control diet	db/m–rapa diet	db/db–control diet	db/db–rapa diet
Body weight (g)	37.22±1.2	37.35±1.5	30.76±3.4*	26.81±1.6
Glucose (mg/dl)	86.06±4.7	80.25±4.1	446.1±47.2***	442.2±40.3
Creatinine (mg/dl)	0.44±0.03	0.36±0.02	0.51±0.04	0.48±0.05
BUN (mg/dl)	20.37±1.2	21.16±0.9	23.08±2.1	22.91±2.6
ALP (IU/L)	40.63±2	45.95±1.4	88.43±8.7***	92.09±8.3
ALT (IU/L)	27.37±3	35.21±5	43.00±5	42.00±2
Total protein (g/dl)	4.81±0.08	4.85±0.06	5.60±0.1***	5.35±0.2
Total cholesterol (mg/dl)	71.74±3.2	70.32±2.6	111.9±10.5***	96.91±5.5
Total triglycerides (mg/dl)	103.5±4.6	92.6±2.5	139.3±13***	89.9±8.6†††

*p<0.05 vs. dbm-control diet

***p<0.001 vs. dbm-control diet

^††† p<0.001 vs. db/db mice on control diet