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. 2004 Feb 2;101(6):1508–1513. doi: 10.1073/pnas.0308250100

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Copyright © 2004, The National Academy of Sciences

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Fig. 4. — Signaling of V1a/VRR1 receptor. (A) Dose-response curve of AVP-induced calcium production mediated by the HEK293 cells stably expressing chimeric receptor and transiently cotransfected with aequorin plasmid. (B) Dose-response curve of AVP for stimulation of adenylyl cyclase activity mediated by control HEK293 cells (square) and HEK293 cells stably expressing chimeric receptor (triangle). (C) Attenuation of V1a/VRR1 response to AVP by point mutations in the receptor. Shown are dose-response curves of AVP-induced calcium production mediated by HEK293 cells transiently cotransfected with aequorin and V1a/VRR1 receptor (squares) or V1a/VRR1(D96A) receptor (triangles) or with V1a/VRR1(Q107A) receptor (diamonds). The data are represented as the mean of two independent experiments, each done in duplicate or triplicate.