Supplementary Table 1.

Fate and animal numbers per initiated cohort

	Found dead	Moribund kills	Cross-sectional kill	Total
Life span cohorts:
Ercc1 −/Δ7 males	8	23	not applicable	31
Ercc1 −/Δ7 females	10	19	not applicable	29
Ercc1 +/+ males	21	29	not applicable	50
Ercc1 +/+ females	10	41	not applicable	51
Cross-sectional cohorts:
Ercc1 −/Δ7 males, 4 weeks	0	0	15	15
Ercc1 −/Δ7 males, 10 weeks	0	0	7	7
Ercc1 −/Δ7 males, 14 weeks	1	0	7	8
Ercc1 −/Δ7 males, 16 weeks	2	1	11	14
Ercc1 −/Δ7 males, 20 weeks	6	6	4	16
Ercc1 −/Δ7 females, 4 weeks	0	0	15	15
Ercc1 −/Δ7 females, 10 weeks	0	0	7	7
Ercc1 −/Δ7 females, 14 weeks	3	1	6	10
Ercc1 −/Δ7 females, 16 weeks	1	1	12	14
Ercc1 −/Δ7 females, 20 weeks	8	2	6	16
Ercc1 +/+ males, 4 weeks	0	0	6	6
Ercc1 +/+ males, 10 weeks	0	0	6	6
Ercc1 +/+ males, 13 weeks	0	0	15	15
Ercc1 +/+ males, 52 weeks	0	0	15	15
Ercc1 +/+ males, 96 weeks	4	1	12	17
Ercc1 +/+ females, 4 weeks	0	0	7	7
Ercc1 +/+ females, 10 weeks	0	0	7	7
Ercc1 +/+ females, 13 weeks	0	0	15	15
Ercc1 +/+ females, 52 weeks	0	0	16	16
Ercc1 +/+ females, 96 weeks	2	1	15	18