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Effect of infection route on survival of Lewis rats. (A) Shows survival of Lewis rats after either subcutaneous (blue line; n = 5) or aerosol exposure (red line; n = 6). The rats that survived s.c. exposure were re-exposed to RVFV by aerosol infection 28 days after the original exposure (green line; n = 5). (B,C) Change in body weight and body temperature of Lewis rats after exposure to RVFV as outlined in (A). The purple line shows the single rat that survived aerosol re-challenge.
