Table 3.
Comparison of disease outcome of different rat strains after subcutaneous or aerosol exposure to RVFV.
| Rat strain | Dose (pfu) | Subcutaneous* | Aerosol | Comparison S.C. vs. Aerosol | ||
|---|---|---|---|---|---|---|
| Ave % mortality | Time to death (days) | Ave % mortality | Time to death (days) | |||
| Wistar-Furth | 103 | 90 | 3 | 100 | 4 | Severe hepatic disease; similar time frame and clinical signs |
| ACI | 103 | 10 | 15 | 100 | 6 | Neurological disease; similar clinical signs; shorter time frame and increased lethality by aerosol |
| Lewis | 103 | 0 | N/A | 100 | 7 | High lethality at modest doses by aerosol |
*
Subcutaneous exposure data from Peters and Slone (1982).