Table 1.
We searched the literature and conducted BLASTP homology searches, followed by reciprocal best-hit analysis, to assemble a list of Leishmania homologs of the putative regulators or effectors of PCD.
| Human homolog (UniProt) | BLASTP reciprocal best-hit | High-score | Expectation value | Reference(s) |
|---|---|---|---|---|
| Endonuclease G | LmjF.10.0610 | 150 | 4.1e-22 | Gannavaram et al., 2008 |
| (Q14249) | LinJ.10.0660 | 147 | 3.0e-21 | BoseDasgupta et al., 2008 |
| Rico et al., 2009 | ||||
| TatD deoxyribonuclease | LmjF.11.1280 | 599 | 2.2e-59 | Gannavaram and Debrabant, 2012 |
| (Q6P1N9) | LinJ.11.1270 | 593 | 9.6e-59 | |
| BoseDasgupta et al., 2008 | ||||
| Flap endonuclease 1 | LmjF.27.0250 | 909 | 1.6e-92 | BoseDasgupta et al., 2008 |
| (FEN1) (P39748) | LinJ.27.0260 | 905 | 4.2e-92 | |
| Apoptosis-inducing factor 1 | LmjF.32.3310 | 111 | 0.00049 | none |
| (AIF1) (O95831) | LinJ.32.3510 | 114 | 0.00023 | |
| Apoptotic protease-activating factor 1 | LmjF.10.0780 | 299 | 2.2e-25 | none |
| (O14727) | LinJ.10.0830 | 303 | 5.1e-26 |
We identified homologs for five of such regulators or effectors of PCD. Some of these molecules have been characterized in terms of their biochemical activities and role in PCD but others need future studies. We did not identify homologs for any of the other mitochondrial or other organelles based molecules with roles in metazoan apoptosis (http://stke.sciencemag.org/cgi/cm/stkecm; CMP_18019; Bergmann and Steller, 2010).