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Physical characteristics of the original tenofovir and RG-tenofovir gels
| Test | Tenofovir gel | RG-tenofovir gel |
|---|---|---|
| Drug content (%, w/w) | 1% | 1.0041% |
| Viscosity (cps, 10 rpm at 25°C) | 9921 | 9161 |
| Rheological profile | shear thinning, pseudoplastic | shear thinning, pseudoplastic |
| pH | 4.5 | 4.6 |
| Osmolality (mmol/kg) | 3111 ± 10 | 836 ± 11 |
| Spreadability (g · s) | 49.732 ± 1.008 | 34.987 ± 2.705 |
| Firmness (g) | 71.257 ± 0.714 | 52.070 ± 1.075 |
| In vitro release rate (μg/cm2/min0.5) | 81.014 | 94.775 |
