Table II.

Performance of ELISA and/or LIPS for the diagnosis of primary SjS.

Test	Sensitivity	Specificity
ELISA
SSA (Ro52 and Ro60)*	72% (41/57)
SSB (La)†	46% (26/57)
SSA & SSB‡	77% (44/57)
LIPS¶
La (mean plus 3 SD)	75% (43/57)	100%
La (mean plus 5 SD)	72% (41/57)	100%
Ro52 (mean plus 3 SD)	61% (35/57)	96%
Ro52 (mean plus 5 SD)	60% (34/57)	100%
Ro60 (mean plus 3 SD)	63% (36/57)	96%
Ro60 (mean plus 5 SD)	61% (35/57)	100%
Ro52 & Ro60 (mean plus 3 SD)	68% (39/57)	92%
Ro52 & Ro60 (mean plus 5 SD)	68% (39/57)	100%
La & Ro52 (mean plus 3 SD)	77% (44/57)	96%
La & Ro52 (mean plus 5 SD)	74% (42/57)	100%
TPO (mean plus 3 SD)	14% (8/57)	100%
TPO (mean plus 5 SD)	11% (6/57)	100%
H + /K + ATPase (mean plus 3 SD)	16% (9/57)	96%
H + / K + ATPase (mean plus 5 SD)	14% (8/57)	100%
AQP-4 (mean plus 3 SD)	12% (7/57)	100%
AQP-4 (mean plus 5 SD)	11% (6/57)	100%
La, Ro52, TPO & AQP-4 (mean plus 3 SD)	86% (49/57)	96%
La, Ro52, TPO & AQP-4 (mean plus 5 SD)	79% (45/57)	100%

^*Includes 1 ELISA borderline positive cases.;

^†Includes 3 ELISA borderline positive case.;

^‡Includes 2 ELISA borderline positive case.;

^¶For LIPS, the cut-off limit for calculating sensitivity and specificity for each antigen was derived from the value of the mean plus 3 or 5 SDs of the 25 control samples.