TABLE 2.
Comparisons of mean pre- and 18-month postsurgical neurobehavioral test scores among 168 patients with SSC and 115 nonsynostotic controls*
| Mean Test Score† | Patient–Control Difference‡ | ||||
|---|---|---|---|---|---|
| Visit & Neurobehavioral Assessments | Patients | Controls | Mean Difference | 95% CI | p Value |
| presurg | |||||
| BSID-II | |||||
| MDI | 92.08 | 94.99 | −2.64 | −4.81 to −0.47 | 0.017 |
| PDI | 84.85 | 88.93 | −4.04 | −6.78 to −1.29 | 0.004 |
| PLS-3 | |||||
| PLS-AC§ | 5.19 | 5.63 | −0.43 | −0.74 to −0.12 | 0.007 |
| PLS-EC | 5.36 | 5.30 | 0.03 | −0.36 to 0.43 | 0.871 |
| PLS-TL§ | 10.58 | 10.93 | −0.37 | −0.94 to 0.20 | 0.204 |
| postsurg (18 mos) | |||||
| BSID-II | |||||
| MDI | 90.59 | 94.78 | −3.04 | −6.16 to 0.08 | 0.056 |
| PDI | 83.20 | 85.73 | −3.16 | −5.84 to −0.48 | 0.021 |
| PLS-3 | |||||
| PLS-AC§ | 13.62 | 14.21 | −0.71 | −1.37 to −0.04 | 0.036 |
| PLS-EC | 13.11 | 13.59 | −0.63 | −1.30 to 0.05 | 0.070 |
| PLS-TL§ | 26.80 | 28.14 | −1.5 | −2.80 to −0.20 | 0.024 |
| postsurg differences adjusted for presurg differences | |||||
| BSID-II | |||||
| MDI | — | — | −1.90 | −4.91 to 1.11 | 0.215 |
| PDI | — | — | −1.71 | −4.26 to 0.83 | 0.188 |
| PLS-3 | — | — | |||
| PLS-AC§ | — | — | −0.53 | −1.18 to 0.13 | 0.116 |
| PLS-EC | — | — | −0.62 | −1.30 to 0.05 | 0.071 |
| PLS-TL§ | — | — | −1.43 | −2.74 to −0.13 | 0.032 |
*
Probability values for tests of whether the patient–control differences were themselves different between the two time points ranged from 0.07 (for the PLS auditory and total language scales) to 0.4 (for all other scales). Abbreviations: CI = confidence interval; presurg = presurgical; postsurg = postsurgical.
†
Mean scores on the BSID-II are average age-standardized scores, whereas mean scores on the PLS-3 are average raw scores.
‡
Adjusted for participants’ study site, age at assessment (in months), SES (Hollingshead index, measured continuously), race (Caucasian vs. other), and sex.
§
Two patients are missing.