TABLE 4.

Comparison of Endpoints for Adjuvant Treatments

Events	Endpoints
	Disease-Free Survival	Recurrence-Free Survival	Overall Survival
Locoregional recurrence	Event	Event	Ignore
Distant metastases	Event	Event	Ignore
Second primary (same cancer)	Event	Ignore	Ignore
Second primary (another cancer)	Event	Ignore	Ignore
Death from the same cancer	Event	Event	Event
Death from another cancer	Event	Ignore	Event
Non–cancer-related death	Event	Ignore	Event
Treatment-related death	Event	Ignore	Event
Lost to follow-up	Censor	Censor	Censor

NOTE: Adapted with permission from Journal of the National Cancer Institute.⁴³ Copyright 2007, Oxford University Press.