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. 2004 Feb 2;101(6):1589–1594. doi: 10.1073/pnas.0305802101

Fig. 2.

Fig. 2.

Cl- current potentiation in VDR WT osteoblasts is selective for 1,25D. Average fold increase of outward Cl- currents measured at 60 mV, 5–10 min after the addition of 5 nM 1,25D (n = 12 VDR WT and n = 11 KO osteoblasts), 0.1–1 μM cholesterol (Ch, n = 5), 10 nM of the synthetic analog 1β,25D by itself (n = 3) or followed by the addition of 5 μM 1,25D (n = 3), 5 nM the natural metabolite 25D (n = 4), and 0.1–1 μM17β-estradiol (17β-E, n = 4) to the bath. The magnitude of the response was compared to the fold increase obtained with 5 nM 1,25D on VDR WT osteoblasts. Values represent the mean ± SEM. *, P < 0.05; **, P < 0.01.