Table 2.

Toxicity of Everolimus at 10 mg/day (n=25)

Toxicity	Any Grade	Grade 3	Grade 4
Fatigue	13 (52)	–	–
Hyperglycemia	12 (48)	1 (4)	–
Anemia	11 (44)	–	1 (4)
Diarrhea	11 (44)	–	–
Leukopenia	10 (40)	–	–
Platelets	10 (40)	–	–
Aspartate transaminase	9 (36)	3 (12)	–
Hyponatremia	9 (36)	2 (8)	–
Anorexia	9 (36)	–	–
Lymphopenia	8 (32)	3 (12)	–
Stomatitis	7 (28)	–	–
Rash/Desquamation	7 (28)	1 (4)	–
Alanine transaminase	6 (24)	1 (4)	–
Neutropenia	5 (20)	–	–
Alkaline phosphatase	4 (16)	–	–
Proteinuria	4 (16)	1 (4)	–
Vomiting	4 (16)	–	–
Nausea	4 (16)	–	–
Dyspnea	4 (16)	–	–
Weight loss	3 (12)	–	–
Acne rash	3 (12)	–	–
Edema	3 (12)	–	–
Taste disturbance	3 (12)	–	–
Hypoalbuminemia	2 (8)	–	–
Hypokalemia	2 (8)	–	–
Hypertriglyceridemia	2 (8)	–	–
Fever without neutropenia	2 (8)	–	–
Constipation	2 (8)	–	–
Nose bleeds	2 (8)	–	–
Cough	2 (8)	–	–
Insomnia	2 (8)	–	–
Pruritis/Itching	2 (8)	–	–
Pain	2 (8)	–	–
Total bilirubin	1 (4)	–	–
Hypernatremia	1 (4)	–	–
Hypocalcemia	1 (4)	–	–
Hypercholesterolemia	1 (4)	–	–
Bicarbonate	1 (4)	–	–
Hypoxia	1 (4)	–	1 (4)
Upper airway infection	1 (4)	–	–
Allergic rhinitis	1 (4)	–	–
Ascites	1 (4)	–	–
Distention/Bloating	1 (4)	–	–
Central nervous system	1 (4)	–	–
cerebrovascular ischemia
Dehydration	1 (4)	–	–
Dry mouth	1 (4)	–	–
Flatulence	1 (4)	–	–
Photosensitivity	1 (4)	–	–
Pneumonitis/Pulmonary infiltrates	1 (4)	–	–

Data are presented as no. (%).