Fig. 7.

A model of Shigella evasion of autophagy (upper panel), and the strategy used by intracellular Shigella to escape from autophagy (lower panel). Shigella are capable of multiplying within the cytoplasm of epithelial cells and moving into adjacent epithelial cells. However, Shigella lacking the icsB gene, which encodes the IcsB effector, and acts as an anti-Atg5 binding factor for VirG, succumbs to autophagy and undergo lysosomal degradation. The upper right panel shows the VirG protein at one pole of bacterium, which is required for the actin-based bacterial motility.