Table 2.

Studies of remifentanil use with regional anesthesia

Study	Surgery	Type of regional	Control group	Study group	N	Measured outcome	Adverse effects
Lauwers et al19	Orthopedic	Spinal or brachial plexus	Placebo with midazolam	Remifentanil infusion with midazolam	160	>sedation and <midazolam required in study group	Respiratory depression, PONV, pruritis
Lauwers et al20	Orthopedic	Spinal or axillary	Propofol infusion	Remifentanil infusion	28	Sedation and comfort equal	>respiratory depression and nausea in study group
Mingus et al21	Orthopedic or urologic	Spinal, axillary or ankle	Propofol infusion	Remifentanil infusion	107	>pain relief in study group	>respiratory depression and nausea in study group
Krenn et al23	Carotid endarterectomy	Cervical plexus	Propofol infusion	Remifentanil	60	No difference in sedation or hemodynamic variables	>respiratory depression and PaCO2 in study group
Servin et al22	Orthopedic, urologic, gynecologic, vascular	Neuraxial or peripheral block	Propofol	Remifentanil	125	>pain relief in study group	>respiratory depression and nausea in study group