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. 2012 Jul 31;7(7):e42156. doi: 10.1371/journal.pone.0042156

Table 6. Guideline statements related to clinical findings GOLD (2010)/NICE (2009)/SEPAR-ALAT (2009).

Summary Statements AUDIPOC results for patients grouped by hospital
Clinical findings Variable Median IRQ Min-Max
An exacerbation of COPD is characterised by a change in the patient’sbaseline dyspnoea, cough, and/or sputum production or colour Increased dyspnoea 96 93–100 84–100
Increased sputum 64 54–72 9–100
Increased purulence 88 80–100 17–100
None of the symptoms 0 0–4 0–13
Anthonisen Type I 40 30–49 7–100
Anthonisen Type II 26 19–32 0–50
Anthonisen Type III 31 23–40 0–91
Diagnosis Variable Median IRQ Min-Max
For patients that require hospitalisation, measurement of arterial bloodgases is important to assess the severity of an exacerbation. Cases with a blood gas analysisin the emergency room 95 88–100 33–100
Inspired oxygen concentrationrecorded in the ED 93 73–100 0–100
Oxygen therapy Variable Median IRQ Min-Max
Oxygen therapy is the cornerstone of hospital treatment of COPDexacerbations and Supplemental oxygen should be titrated to improve thepatient’s hypoxemia Cases receiving oxygen duringadmission 98 95–100 53–100
Pulse-oxymetry while receivingoxygen- therapy 98 86–100 0–100
Bronchodilators Variable Median IRQ Min-Max
Management of COPD exacerbations involves increasing the doseand/or frequency of existing short-acting bronchodilator therapy, preferablywith a ß2 agonist. Cases on short-actingbronchodilators 98 94–100 61–100
Cases on short-acting ß2 agonists 93 85–97 11–100
Cases on ipratropium 94 88–100 15–100
Antibiotics Variable Median IRQ Min-Max
Antibiotics should be given to patients with three cardinal symptoms,with two cardinal symptoms if purulence of sputum is one of the twosymptoms, and patients that require mechanical ventilation Cases on antibiotics withthree cardinal symptoms 98 90–100 50–100
Cases on antibiotics with anincrease in sputum purulence 97 91–100 0–100
Cases on ventilatorsupport receiving antibiotics 100 83–100 0–100
Steroids Variable Median IRQ Min-Max
In the absence of significant contraindications oral corticosteroids shouldbe used, in conjunction with other therapies, in all patients admitted to hospitalwith an exacerbation of COPD. Cases on oral or intravenousglucocorticosteroids 94 89–98 50–100
Discharge report Variable Median IRQ Min-Max
Opportunities for prevention of future exacerbations should be reviewedbefore discharge, with particular attention to smoking cessation, currentvaccination (influenza, pneumococcal vaccines), knowledge of current therapyincluding inhaler technique and how to recognize symptoms of exacerbations. Anti-tobacco instructions inactive smokers 43 23–63 0–100
Influenza vaccination instructions 0 0–7 0–100
Pneumococcal vaccinationinstructions 0 0–3 0–100
Nutritional instructions 37 21–53 0–100
Inhaler technique instructions 7 0–19 02100
Programmed visit after discharge 95 89–100 30–100