Table 1.
Metabolic syndrome at age 24 and potential risk factors at age 14: race, free testosterone, estradiol, dehydroepiandrosterone sulfate, sex hormone binding globulin, oligomenorrhea (menses delay ≥42 days), metabolic syndrome, and childhood insulin
| Age 14 variables | n | Median, interquartile range (IQ) | Metabolic Syndrome Yes at age 24 (n=35) | Metabolic Syndrome no at age 24 (n=385) | Fisher’s p |
|---|---|---|---|---|---|
| WHITE (n=194) | |||||
| FreeT (pg/ml) | 194 | 1.16 (0.75, 1.63) | 14% (2/14) in race-spec. top decile | 8% (15/180) in race-spec. top decile | .35 |
| E2 (pg/ml) | 194 | 76.7 (50.3, 135.8) | 14% (2/14) in race-spec. bottom decile | 7% (13/180) in race-spec. bottom decile | .30 |
| DHEAS (mcg/dl) | 194 | 159.2 (109.1, 236.9) | 14% (2/14) in race-spec. top decile | 10% (18/180) in race-spec. top decile | .64 |
| SHBG (nmol/l) | 194 | 18 (12, 24) | 50% (7/14) in race-spec. bottom decile | 8% (14/180) in race-spec. bottom decile | .0001* |
| Insulin (uU/ml) | 176 | 8.8 (5.6, 12.9) | 42% (5/12) in race-spec. top decile | 7% (11/164) in race-spec. top decile | .0018* |
| Oligomenorrhea at age 14 | 153 | 12 Yes (8%) | 18% (2/11) had oligomenorrhea | 7% (10/142) had oligomenorrhea | .21 |
| MetS at age 14 | 194 | 11 Yes (6%) | 36% (5/14) had MetS at age 14 | 3% (6/180) had MetS at age 14 | .0003* |
| BLACK (n=226) | |||||
| FreeT (pg/ml) | 226 | 1.06 (0.65, 1.43) | 29% (6/21) in race-spec. top decile | 8% (17/205) in race-spec. top decile | .011* |
| E2 (pg/ml) | 225 | 90.7 (53.7, 187.5) | 10% (2/21) in race-spec. bottom decile | 10% (20/204) in race-spec. bottom decile | 1.0 |
| DHEAS (mcg/dl) | 226 | 165.2 (117.1, 226) | 14% (3/21) in race-spec. top decile | 9% (19/205) in race-spec. top decile | .44 |
| SHBG (nmol/l) | 226 | 17 (11, 24) | 33% (7/21) in race-spec. bottom decile | 7% (14/205) in race-spec. bottom decile | .0011* |
| Insulin (uU/ml) | 203 | 12.5 (7.9, 20.8) | 40% (8/20) in race-spec. top decile | 7% (13/183)) in race-spec. top decile | .0002* |
| Oligomenorrhea at age 14 | 212 | 18 Yes (8%) | 15% (3/20) had oligomenorrhea | 8% (15/192) had oligomenorrhea | .39 |
| MetS at age 14 | 226 | 16 Yes (7%) | 38% (8/21) had MetS at age 14 | 4% (8/205) had MetS at age 14 | <.0001* |
| TOTAL COHORT (n=420) | |||||
| Race | 420 | 60% (21/35) black | 53% (205/385) black | .44 | |
| FreeT (pg/ml) | 420 | 1.07 (0.71, 1.51) | 23% (8/35) in race-spec. top decile | 8% (32/385) in race-spec. top decile | .011* |
| E2 (pg/ml) | 419 | 84.9 (52.3, 160.8) | 11% (4/35) in race-spec. bottom decile | 9% (33/384) in race-spec. bottom decile | .53 |
| DHEAS (mcg/dl) | 420 | 161.8 (115.3, 228.4) | 14% (5/35) in race-spec. top decile | 10% (37/385) in race-spec. top decile | .38 |
| SHBG (nmol/l) | 420 | 17 (12, 24) | 40% (14/35) in race-spec. bottom decile | 7% (28/385) in race-spec. bottom decile | <.0001* |
| Insulin (uU/ml) | 379 | 10.5 (6.7, 16.4) | 41% (13/32) in race-spec. top decile | 7% (24/347) in race-spec. top decile | <.0001* |
| Oligomenorrhea at age 14 | 365 | 30 Yes (8%) | 16% (5/31) had oligomenorrhea | 7% (25/334) had oligomenorrhea | .16 |
| MetS at age 14 | 420 | 27 Yes (6%) | 37% (13/35) had MetS at age 14 | 4% (14/385) had MetS at age 14 | <.0001* |
*
significant using Hochberg-Benjamini method controlling for false discovery rate (p<.05), 7 tests in each race group, 8 tests in race-pooled group
Abbreviations: Free testosterone = FreeT, estradiol = E2, dehydroepiandrosterone sulfate = DHEAS, sex hormone binding globulin = SHBG, MetS = metabolic syndrome