Table 3.
Genes down-regulated by hydrogen peroxide in Entamoeba histolytica HM-1:IMSS. The probe ID, accession number, description, baseline expression level, fold-change, p-value, and regulation under DPTA or other conditions are shown. The 30 most highly regulated genes are listed. HS (heat shock) (adapted from Hackney et al); Colitis (ameba from a mouse model of amebic colitis) (adapted from Gilchrist et al); Trophs (E. histolytica trophozoites) (adapted from Ehrenkaufer et al).
| Probe ID | Accession number | Description | Baseline expression level | Fold-change | p-value | Regulated under DPTA | Regulated under other conditions? |
|---|---|---|---|---|---|---|---|
| 172.m00078_at | XM_646199 | hypothetical protein | 0.86 | −9.09 | 0.000 | + | HS |
| 537.m00017_x_at | XM_643063 | AIG1 family protein, putative | 4.58 | −7.41 | 0.039 | + | - |
| 2.m00528_at | XM_652349 | hypothetical protein | 0.35 | −6.8 | 0.019 | + | HS |
| 3.m00563_at | XM_652186 | hypothetical protein | 6.39 | −5.75 | 0.002 | + | - |
| 86.m00158_s_at | XM_648244 | hypothetical protein | 0.46 | −5.59 | 0.039 | + | HS |
| 226.m00092_at | XM_645246 | Rab family GTPase | 0.26 | −4.83 | 0.000 | + | - |
| 233.m00105_at | XM_645153 | hypothetical protein | 6.57 | −4.41 | 0.004 | + | - |
| 9.m00372_x_at | XM_651612 | hypothetical protein | 0.32 | −4.18 | 0.004 | + | HS |
| 87.m00165_at | XM_648195 | hypothetical protein | 0.21 | −4.13 | 0.009 | + | - |
| 87.m00154_at | XM_648212 | formate nitrite transporter family protein, putative | 0.78 | −4.02 | 0.001 | - | Colitis |
| 31.m00209_x_at | XM_650257 | conserved hypothetical protein | 0.25 | −3.79 | 0.019 | + | - |
| 66.m00150_at | XM_648887 | high mobility group protein, putative | 0.39 | −3.77 | 0.006 | + | HS |
| 343.m00064_x_at | XM_644015 | WD repeat protein | 0.21 | −3.76 | 0.039 | + | - |
| 125.m00091_at | XM_647175 | cyclin, putative | 0.71 | −3.69 | 0.006 | + | HS |
| 286.m00057_at | XM_644512 | mitotic inducer phosphatase, putative | 0.21 | −3.31 | 0.000 | + | HS |
| 37.m00216_at | XM_649962 | hypothetical protein | 0.79 | −3.26 | 0.018 | + | - |
| 56.m00175_at | XM_649238 | elongation factor 1 beta, putative | 12.26 | −3.15 | 0.038 | - | - |
| 46.m00250_at | XM_649627 | hypothetical protein | 3.53 | −3.07 | 0.005 | - | - |
| 19.m00301_at | XM_650878 | hypothetical protein | 2.32 | −3.03 | 0.015 | + | HS |
| 408.m00045_s_at | XM_643583 | putative GTPase | 2.43 | −3.02 | 0.006 | + | HS |
| 80.m00159_at | XM_648429 | hypothetical protein | 7.76 | −2.99 | 0.004 | + | - |
| 1.m00606_s_at | XM_652473 | hypothetical protein | 9.86 | −2.91 | 0.006 | + | HS |
| 40.m00246_s_at | XM_649855 | rRNA biogenesis protein, putative | 4.83 | −2.89 | 0.041 | + | HS |
| 95.m00147_at | XM_647953 | PfkB family carbohydrate kinase, putative | 6.85 | −2.89 | 0.005 | - | HS |
| 51.m00159_s_at | XM_649424 | hypothetical protein | 0.30 | −2.88 | 0.031 | + | - |
| 221.m00089_s_at | XM_645315 | hypothetical protein | 3.74 | −2.85 | 0.027 | + | - |
| 127.m00147_at | XM_647143 | predicted protein | 1.33 | −2.82 | 0.019 | + | HS |
| 4.m00641_at | XM_652060 | tRNA-specific adenosine deaminase, putative | 13.13 | −2.8 | 0.040 | + | - |
| 34.m00273_at | XM_650116 | Rab family GTPase | 4.84 | −2.77 | 0.048 | - | Trophs |
| 13.m00334_at | XM_651296 | conserved hypothetical protein | 2.85 | −2.67 | 0.027 | + | Trophs |