Table 5.
Genes down-regulated by DPTA-NONOate in Entamoeba histolytica HM-1:IMSS. The probe ID, accession number, description, baseline expression level, fold-change, p-value, and regulation under other conditions are shown. The 30 most highly regulated genes are listed. HS (heat shock) (adapted from Hackney et al); Colitis (ameba from a mouse model of amebic colitis) (adapted from Gilchrist et al); Trophs (E. histolytica trophozoites) (adapted from Ehrenkaufer et al).
| Probe ID | Accession number | Description | Baseline expression level | Fold-change | p-value | Regulated under other conditions? |
|---|---|---|---|---|---|---|
| 4.m00678_s_at | XM_652013 | hypothetical protein | 41.94 | −49.02 | 0.002 | - |
| 172.m00078_at | XM_646199 | hypothetical protein | 0.86 | −14.43 | 0.001 | HS |
| 99.m00179_at | XM_647858 | inositol polyphosphate kinase, putative | 4.53 | −11.48 | 0.001 | - |
| 341.m00039_s_at | XM_644035 | hypothetical protein | 2.41 | −10.59 | 0.015 | - |
| 229.m00063_at | XM_645215 | hypothetical protein | 5.04 | −9.35 | 0.019 | - |
| 221.m00089_s_at | XM_645315 | hypothetical protein | 3.74 | −9.01 | 0.002 | - |
| 13.m00349_at | XM_651311 | protein kinase, putative | 2.17 | −8.85 | 0.004 | - |
| 65.m00147_at | XM_648922 | hypothetical protein | 2.93 | −8.47 | 0.003 | Trophs + HS |
| 255.m00049_at | XM_644881 | conserved hypothetical protein | 1.25 | −8.2 | 0.022 | - |
| 93.m00151_at | XM_648019 | WD repeat protein | 1.99 | −8.2 | 0.004 | - |
| 22.m00263_at | XM_650739 | hypothetical protein | 1.42 | −7.94 | 0.019 | - |
| 74.m00199_at | XM_648611 | hypothetical protein | 2.53 | −7.87 | 0.001 | - |
| 232.m00071_at | XM_645176 | hypothetical protein | 1.15 | −7.46 | 0.004 | - |
| 4.m00607_at | XM_652082 | protein kinase, putative | 3.19 | −7.46 | 0.002 | HS |
| 408.m00044_at | XM_643584 | hypothetical protein | 0.95 | −7.46 | 0.043 | - |
| 86.m00158_s_at | XM_648244 | DEAD DEAH box helicase, putative | 0.46 | −7.35 | 0.044 | HS |
| 32.m00207_at | XM_650196 | zinc finger protein, putative | 12.62 | −6.94 | 0.009 | - |
| 32.m00202_s_at | XM_650191 | hypothetical protein | 0.72 | −6.9 | 0.008 | - |
| 4.m00640_at | XM_652059 | conserved hypothetical protein | 3.07 | −6.9 | 0.000 | - |
| 113.m00152_at | XM_647500 | BspA-like leucine rich repeat protein, putative | 1.09 | −6.85 | 0.015 | Trophs |
| 289.m00071_s_at | XM_644481 | putative GTPase | 7.01 | −6.29 | 0.000 | - |
| 82.m00139_s_at | XM_648379 | hypothetical protein | 0.59 | −6.21 | 0.005 | - |
| 408.m00045_s_at | XM_643583 | hypothetical protein | 2.43 | −6.17 | 0.007 | HS |
| 2.m00528_at | XM_652349 | protein phosphatise, putative | 0.35 | −5.99 | 0.028 | HS |
| 201.m00110_at | XM_645662 | hypothetical protein | 1.35 | −5.92 | 0.006 | HS |
| 12.m00322_at | XM_651338 | hypothetical protein | 3.67 | −5.81 | 0.030 | HS |
| 48.m00216_s_at | XM_649527 | hypothetical protein | 3.05 | −5.75 | 0.019 | Colitis |
| 98.m00148_s_at | XM_647890 | hypothetical protein | 1.02 | −5.52 | 0.001 | - |
| 66.m00150_at | XM_648887 | hypothetical protein | 0.39 | −5.49 | 0.000 | HS |
| 816.m00009_at | XM_642817 | hypothetical protein | 4.41 | −5.38 | 0.049 | HS |