Figure 2.

In vitro degradation of IgG under GI-mimicking conditions. ¹²⁵I-IgG was incubated for the indicated time periods in SGF with or without pepsin, or SIF with or without pancreatin, and the percentage of ¹²⁵I-IgG degradation was calculated as described in Figure 1. Curves were fitted by software regression analysis.

Note: Data are mean ± SEM (n ≥ 3 per experiment and at least two independent experiments).

Abbreviations: SGF, simulated gastric fluid; SIF, simulated intestinal fluid; SEM, standard error of the mean.