6-W dose response over time. Abbreviations: BL, baseline; T-2, mean during minute 2 of treatment; T-3, mean during minute 3 of treatment; T-4, mean during minute 4 of treatment; PT-1, mean at posttreatment minute 1; PT-2, mean at posttreatment minute 2; PT-3, mean at posttreatment minute 3; PT-4, mean at post-treatment minute 4; PT-5, mean at posttreatment minute 5.