Table 1. Generation of chimeric heteroplasmic founder mice.
| ES cells | Clone | Ova injected | Founders | Weaned | Chimeras |
|---|---|---|---|---|---|
| Ms xenocybrid | S2 | 227 | 66 | 42 | 13/61 |
| S3 | 194 | 28 | 14 | 5/26 | |
| Md xenocybrid | D6 | 169 | 43 | 30 | 7/38 |
| D7 | 546 | 102 | 53 | 22/96 |
Chimeric heteroplasmic founder mice generated from different ES xenomitochondrial cybrid clones. All ES cell clones used were homoplasmic by restriction digest analysis.