Figure 1.

Typical morphology and immunophenotype of CD20-negative diffuse large B-cell lymphoma ranged from A to L. A (Hematoxylin-Eosin staining): Diffuse proliferation of large tumor cells with large nucleus, prominent nucleoli, abundant cytoplasm, and the karyokinesis were easy to be observed; B: Tumor cells were positive for CD45 (LCA); C: Tumor cells were negative for CD20; D: Tumor cells were positive for CD79a; E-F: Tumor cells were negative for CD3, CD5; G: Tumor cells were strong positive for CD30; H-I: Tumor cells were negative for CD10 and BCL-6; J: Tumor cells were positive for MUM-1; K: Tumor cells had a very high proliferation index with Ki-67 highlighting more than 90% tumor cells; L: Tumor cells were negative for EBERs ISH.