Table 1.

Summary of in vivo magnolol effect on cardiovascular system

Dosage	Effect	Reference
Low (10-7~10-4 mg/kg)
10-7~−6 mg/kg (i.v.)	Prevent post MI‒induced ventricular arrythmia	[16,18]
10-5 mg/kg (i.v.)	Decrease MI‒induced infarct size	[16]
Moderate (10-4~10-2 mg/kg)
10-4~−3 mg/kg (i.v.)	Protect myocardium against MI‒induced myocardial wall thinning	[19]
2-5 × 10-4 mg/kg (i.v.)	Decrease neutrophil infiltration in infarct heart	[20]
10-3 mg/kg (i.m.) daily	Attenuate balloon‒induced intimal thickening and inhibit LDL oxidation	[24]
10-3 mg/kg (i.m.) daily	Attenuate hypercholesteremia‒induced intimal thickening, TNFα and VCAM‒1 elevation in an aorta.	[40]
High (≧10-1 mg/kg)
10-1 mg/kg (i.v.)	Reduce coronary artery resistance after MI	[21]
10 mg/kg (i.p.)	Prevent MI‒induced cardiomyocyte apoptosis	[22]

i.v.: intravenous injection; i.m.: intramuscular injection; i.p.: intraperitoneal injection.