Figure 4.

Effect of microRNA (miR)-124 treatment on interleukin (IL)-1β-induced hyperalgesia. (A) LysM-G protein–coupled receptor kinase (GRK)2^+/− and (B) wild-type (WT) mice received an intrathecal injection of 20, 50 or 100 ng miR-124 per mouse or 100 ng negative control miRNA 1 day before intraplantar injection of 1 ng IL-1β and the percentage change in heat-withdrawal latency was determined (n = 4 to 10 per group). Data are expressed as means ± SEM. **P < 0.01, ***P < 0.001 for 50 ng miR-124 versus control miRNA; #P < 0.05, ###P < 0.001 for 100 ng miR-124 versus control miRNA.