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Effect of microRNA(miR)-124 treatment on carrageenan-induced persistent hyperalgesia in wild-type (WT) mice. Wild-type (WT) mice received an intraplantar injection of 20 μl 2% λ-carrageenan. At day 6, mice were still hyperalgesic. At this time point, mice received an intrathecal injection of 100 ng miR-124 or control miRNA, and the percentage change in heat withdrawal latency was determined (miR-124 n = 8; control miRNA n = 4). Data are expressed as means ± SEM. ***P < 0.001.
