Table 3. Estimates of the effect of the rs3732666 and rs1061376 on SBP and DBP phenotypes.
| Systolic Blood Pressure | Diastolic Blood Pressure | |||||
| β | 95%CI | P | β | 95%CI | P | |
| Rs3732666 | ||||||
| Model 1 | ||||||
| AG+GG | −4.95 | −8.94 to −0.96 | 0.015 | −2.09 | −4.08 to−0.11 | 0.039 |
| Model 2 | ||||||
| AG+GG | −3.6 | −7.18 to −0.31 | 0.048 | −1.31 | −3.14 to0.51 | 0.158 |
| Model 2 | ||||||
| 35 years of age | ||||||
| AG+GG | −6.83 | −12.84 to −0.84 | 0.026 | |||
| 45 years of age | ||||||
| AG+GG | −5.94 | −10.37 to −1.50 | 0.009 | |||
| 55 years of age | ||||||
| AG+GG | −3.37 | −6.95 to 0.2 | 0.064 | |||
| 65 years of age | ||||||
| AG+GG | 0.15 | −4.6 to 4.91 | 0.95 | |||
| Rs1061376 | ||||||
| Model 1 | ||||||
| CT | 1.65 | −2.33 to 5.63 | 0.41 | 0.45 | −1.52 to2.43 | 0.65 |
| TT | −8.34 | −14.86 to −1.83 | 0.012 | −3.58 | −6.81 to−0.34 | 0.03 |
| Model 2 | ||||||
| CT | −0.56 | −4.13 to 3.02 | 0.75 | −0.47 | −2.3 to1.35 | 0.61 |
| TT | −7.91 | −13.73 to −2.07 | 0.008 | −3.69 | −6.67 to−0.71 | 0.015 |
Estimates were derived applying linear regression to the overall population (n = 791). For both genotypes, model 1 is a crude model while model 2 is adjusted for gender, age, BMI, and smoking. For rs3732666, SBP and DBP measurements in AA and AG+GG genotypes were 134.98 and 130.47, and 83.40 and 81.65 mmHG, respectively. For rs1061376, SBP and DBP measurements in CC, CT, and TT genotypes were 133.38, 134.38, and 125.75 and 82.92, 82.97, and 79.69 mmHg, respectively.