Table 2. Bone volume, assessed by micro-CT of tibiae, from 12 week old mice.
Males | Females | |||
WT (+/+) (n = 4) | Tcal/Tcal (n = 5) | WT (+/+) (n = 4) | Tcal/Tcal (n = 5) | |
BV/TV (%) | 10.3±1.3 | 17.7±3.0 | 14.4±2.4 | 18.8±1.1 |
Tb. Th (mmx10−2) | 4.2±0.05 | 4.0±0.1 | 5.1±0.2 | 5.4±0.2 |
Tb. N (mm−1) | 2.4±0.3 | 4.4±0.7* | 3.3±0.7 | 1.9±0.3 |
SMI | 1.6±0.2 | 0.7±0.1** | 1.5±0.3 | 1.1±0.3 |
C. BV (mm3) | 0.98±0.03 | 1.16±0.04** | 0.89±0.08 | 1.16±0.04* |
WT (+/+), refers to wild-type littermates; BV/TV = trabecular bone volume (BV) fraction as a proportion of total volume (TV) of organ; Tb. Th = trabecular thickness, Tb. N = trabecular number; SMI = structural model index; and C.BV = cortical bone volume. Values represent means ± SEM; Unpaired student’s t-test: *p<0.05, **p<0.01.