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. 2012 Aug 13;7(8):e42955. doi: 10.1371/journal.pone.0042955

Figure 4. Tyr expression was decreased by GPNMB-siRNA transfection.

Figure 4

The mRNA (A) or protein (B) expression levels of Tyr and GPNMB in melanocytes PIG1 treated by UVB radiation, GPNMB-siRNA transfection or both of them were determined using real-time quantitative PCR or Western blotting, respectively. The effect of Tyr-siRNA treatment on GPNMB and Tyr expression levels were also determined using real-time quantitative PCR and Western blotting. Data were normalized based on the β-actin levels and were represented as relative expression levels. *p<0.05 by Student's t test when compared with the control group.