Table 4. Association between fingerprint clustering and M. tuberculosis genotype (Beijing vs. East-African-Indian) by drug resistance patterns among smear-positive pulmonary tuberculosis in rural Vietnam, 2003–2006.
| Drug resistance | East-African-Indian genotypes | Beijing genotypes | p value for interaction 2 | ||||
| Total | In cluster n (%) | Adjusted OR 1(95% CI) | Total | In cluster n (%) | Adjusted OR1 (95% CI) | ||
| Streptomycin | |||||||
| Susceptible | 711 | 478 (67.2%) | 1 | 398 | 134 (33.7%) | 1 | 0.002 |
| Resistant | 91 | 49 (53.9%) | 0.6 (0.4–0.9) | 388 | 158 (40.7%) | 1.3 (1.0–1.8) | |
| Isoniazid | |||||||
| Susceptible | 697 | 458 (65.7%) | 1 | 555 | 192 (34.6%) | 1 | 0.140 |
| Resistant | 105 | 69 (65.7%) | 0.9 (0.6–1.5) | 231 | 100 (43.3%) | 1.5 (1.1–2.1) | |
| Rifampicin | |||||||
| Susceptible | 792 | 520 (66.7%) | 1 | 706 | 260 (36.8%) | 1 | 0.925 |
| Resistant | 10 | 7 (70.0%) | 1.0 (0.3–4.2) | 80 | 32 (40.0%) | 1.2 (0.7–1.9) | |
| Ethambutol | |||||||
| Susceptible | 799 | 525 (65.7%) | 1 | 760 | 281 (37.0%) | 1 | 0.822 |
| Resistant | 3 | 2 (66.7%) | 1.0 (0.1–12.0) | 26 | 11 (42.3%) | 1.3 (0.6–2.9) | |
| Streptomycin and isoniazid | |||||||
| Susceptible | 750 | 479 (66.3%) | 1 | 575 | 200 (34.8%) | 1 | 0.021 |
| Resistant | 52 | 30 (57.7%) | 0.6 (0.4–1.1) | 211 | 92 (43.6%) | 1.5 (1.1–2.1) | |
| Rifampicin and isoniazid | |||||||
| Susceptible | 795 | 522 (65.7%) | 1 | 718 | 267 (37.2%) | 1 | 0.875 |
| Resistant | 7 | 5 (71.4%) | 1.2 (0.2–6.5) | 68 | 25 (36.8%) | 1.0 (0.6–1.7) | |
ORs: Odds ratios, with 95% confident interval CI: Confidence interval.
1
Adjusted by logistic regression modeling for year of inclusion, age, sex, commune of residence and history of tuberculosis treatment.
2
P values based on Wald test for comparison of stratum to reference category. Denotes the level of significance for the difference between East-African-Indian and Beijing genotypes in the association of clustering and drug resistance.