Table 1. Correlations between the clinicopathologic characteristics and dyskerin protein expression in hepatocellular carcinoma.
Characteristics | N | Dyskerin (%) | P * | |
Negative/low expression | High expression | |||
Gender | 0.55 | |||
Male | 209 | 88 (42.1) | 121 (57.9) | |
Female | 43 | 16 (37.2) | 27 (62.8) | |
Age (years) | 0.36 | |||
<60 | 176 | 78 (44.3) | 98 (55.7) | |
> = 60 | 76 | 29 (38.2) | 47 (61.8) | |
HbsAg | 0.00 | |||
Negative | 111 | 70 (63.1) | 41 (36.9) | |
Positive | 141 | 58 (43.1) | 83 (58.9) | |
AFP (ng/ml) | 0.00 | |||
<400 | 153 | 20 (32.0) | 104 (68.0) | |
> = 400 | 99 | 52 (52.5) | 47 (47.5) | |
Tumor size (cm) & § | 0.81 | |||
<5 | 47 | 20 (42.6) | 27 (57.4) | |
> = 5 | 94 | 42 (44.7) | 52 (55.3) | |
Liver cirrhosis § | 0.35 | |||
Absent | 60 | 26 (44.3) | 34 (56.7) | |
Mild | 51 | 25 (49.1) | 26 (50.9) | |
Moderate | 54 | 22 (40.7) | 32 (59.3) | |
Severe | 31 | 9 (29.0) | 22 (71.0) | |
Clinical stage § | 0.00 | |||
I–II | 185 | 102 (55.1) | 83 (44.9) | |
III–IV | 79 | 24 (30.4) | 55 (69.6) | |
Adjacent organs invasion § | 0.27 | |||
Negative | 153 | 78 (51.0) | 75 (49.0) | |
Positive | 74 | 32 (43.2) | 42 (56.8) | |
Reccurrence or metastasis § | 0.66 | |||
Negative | 148 | 57 (38.5) | 91 (61.5) | |
Positive | 76 | 27 (35.5) | 49 (64.5) | |
Tumor encapsulation § | 0.26 | |||
Absent | 114 | 48 (42.1) | 66 (57.9) | |
Present | 109 | 38 (34.9) | 71 (65.1) |
AFP, alpha-fetoprotein; HbsAg, hepatitis B surface antigen.
: Two-tailed chi-Square test. 0.00 indicates <0.01.
&: Tumor size was measured based on the length of the largest tumor nodule.
: Some data were not available, and the statistical analysis was based on the available data.