Table 2. Univariate and multivariate analyses of different prognostic factors with overall survival in 252 patients with HCC (Cox Proportional Hazards Regression).
| Parameter | Univariate analysis | Multivariate analysis | ||||
| P | HR | 95%CI | P | HR | 95%CI | |
| Age (years) | 0.21 | |||||
| <60 | 1.0 | |||||
| > = 60 | 0.67 | 0.41–1.02 | ||||
| Gender | 0.37 | |||||
| Female | 1.0 | |||||
| Male | 1.14 | 0.71–2.36 | ||||
| HbsAg | 0.17 | |||||
| Negative | 1.0 | |||||
| Positive | 1.25 | 0.94–1.67 | ||||
| AFP (ng/ml) | 0.54 | |||||
| <400 | 1.0 | |||||
| > = 400 | 1.37 | 0.62–3.02 | ||||
| Tumor size (cm) & § | 0.07 | |||||
| <5 | 1.0 | |||||
| > = 5 | 1.17 | 0.91–1.51 | ||||
| Liver cirrhosis § | 0.55 | |||||
| Absent | 1.0 | |||||
| Present | 1.23 | 0.78–2.46 | ||||
| Clinical stage § | 0.01 | 0.00 | ||||
| I–II | 1.0 | 1.0 | ||||
| III–IV | 3.21 | 1.89–4.21 | 3.16 | 1.76–3.72 | ||
| Adjacent organs invasion § | 0.08 | |||||
| Negative | 1.0 | |||||
| Positive | 1.48 | 0.94–1.89 | ||||
| Recurrence or metastasis § | 0.01 | 0.00 | ||||
| Negative | 1.0 | 1.0 | ||||
| Positive | 2.76 | 2.19–3.21 | 2.75 | 1.77–3.75 | ||
| Tumor encapsulation § | 0.77 | |||||
| Absent | 1.0 | |||||
| Present | 1.42 | 0.72–2.81 | ||||
| Dyskerin expression | 0.02 | 0.00 | ||||
| Negative/low expression | 1.0 | 1.0 | ||||
| High expression | 1.87 | 1.68–2.54 | 2.91 | 2.84–4.91 | ||
AFP, alpha-fetoprotein; HbsAg, hepatitis B surface antigen; HR, hazards ratio; CI, confidence interval.
0.00 indicates <0.01.
&: Tumor size was measured based on the length of the largest tumor nodule.
§
: Some data were not available, and the statistical analysis was based on the available data.