Table 1. Effects of exemestane on Annexin V-PE labelling in MCF-7aro cells.

6 DAYS	T	T+5 µM	T+10 µM	T+15 µM	T+STS 1 µM
AnnexinV−/7-AAD−	86.69±1.62	84.45±0.15	74.47±2.53*	73.24±3.44*	59.87±1.08***
Annexin V+/7-AAD−	3.67±0.35	5.62±0.45 (1.53)	9.80±0.92** (2.67)	10.04±0.61*** (2.74)	17.40±1.15*** (4.74)
Annexin V+/7-AAD+	9.65±1.28	9.94±0.30 (1.03)	15.57±1.65 (1.61)	16.73±2.85 (1.73)	20.38±2.10** (2.11)

Cells were treated with different concentrations of exemestane for 6 and 9 days. Treated cells were harvested and labeled with Annexin V-PE and 7-AAD followed by flow cytometry analysis. Data are presented as viable cells (Annexin V-/7-AAD-), early apoptotic (Annexin V+/7-AAD-) and late apoptotic or necrotic cells (Annexin V+/7-AAD+). Cells cultured with T at 1 nM were considered as control and cells treated with T plus STS (1 µM) were considered as positive control for apoptosis. The data represents means ± SEM of three independent experiments done in triplicate. The ratio treatment/control is presented in bold within brackets. Significant differences between the control versus treated cells are indicated by

^*(p<0.05),

^**(p<0.01) and

^***(p<0.001).